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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-70340

Genz 669178

Pf DHODH inhibitor

Genz 669178 is a potent PfDHODH inhibitor that exhibits low nanomolar in vitro potency against DHODH from P falciparum, P vivax, and P berghei.
PC-70339

IDI-6273

Pf DHODH inhibitor

IDI-6273 is a potent, mutant-selective PfDHODH inhibitor with IC50 of 210 nM for 3D7 E182D PfDHODH.
PC-70327

S.aureus sortase inhibitor 6e

S.aureus sortase inhibitor

Sortase-IN-6e is a small molecule inhibitor of Staphylococcus aureus sortase with IC50 of 9.3 uM.
PC-70301

Negamycin

Antibiotic

Negamycin is a dipeptide antibiotic that inhibits the initiation of protein synthesis.
PC-61005

GSK951A

EchA6 inhibitor

GSK951A is a small molecule with bactericidal efficacy against Mycobacterium tuberculosis with H37Rv MIC of 0.16 uM, targets enoyl-coenzyme A (CoA) hydratase EchA6 with binding Kd of 0.45 uM.
PC-61004

GSK-729

EchA6 inhibitor

GSK-729 (GSK729) is a potent, small molecule inhibitor of Mycobacterium tuberculosis enoyl-coenzyme A (CoA) hydratase EchA6 with IC50 of 1.8 uM, but not the MmpL3.
PC-60900

M4284

FimH inhibitor

M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.
PC-60869

NSC624548

Antibacterial

NSC624548 (HO-221) is a small molecule that inhibits the activities of E. coli DNA polymerase I and calf thymus DNA polymerase alpha.
PC-70214

BRD4592

Mtb tryptophan synthase inhibitor

BRD4592 is a small-molecule, allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase (TrpAB), binds at the TrpAB α-β-subunit interface with IC50 of 70.9 nM and 22.6 nM for α-subunit and β-subunit, respectively.
PC-60475

Zoliflodacin

DNA gyrase inhibitor

Zoliflodacin (AZD0914, ETX0914) is a novel DNA gyrase inhibitor that inhibits bacterial DNA biosynthesis, has potent in vitro activity against many different bacterial species with MIC of 0.004 to 0.25 ug/ml.
PC-60356

TAM-16

M. tuberculosis Pks13 inhibitor

TAM-16 is a benzofuran class inhibitor of M. tuberculosis Pks13 (Polyketide Synthase 13 with IC50 of 0.32 uM.
PC-70181

RWJ-49815

Kinase A inhibitor

RWJ-49815 is a potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM.

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