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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-60900

M4284

M4284 (M-4284) is a high-affinity biphenyl mannoside FimH inhibitor with HAI of 16 nM in hemagglutination assay.
PC-60869

NSC624548

Antibacterial

NSC624548 (HO-221) is a small molecule that inhibits the activities of E. coli DNA polymerase I and calf thymus DNA polymerase alpha.
PC-70214

BRD4592

Mtb tryptophan synthase inhibitor

BRD4592 is a small-molecule, allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase (TrpAB), binds at the TrpAB α-β-subunit interface with IC50 of 70.9 nM and 22.6 nM for α-subunit and β-subunit, respectively.
PC-60475

Zoliflodacin

DNA gyrase inhibitor

Zoliflodacin (AZD0914, ETX0914) is a novel DNA gyrase inhibitor that inhibits bacterial DNA biosynthesis, has potent in vitro activity against many different bacterial species with MIC of 0.004 to 0.25 ug/ml.
PC-60356

TAM-16

M. tuberculosis Pks13 inhibitor

TAM-16 is a benzofuran class inhibitor of M. tuberculosis Pks13 (Polyketide Synthase 13 with IC50 of 0.32 uM.
PC-70181

RWJ-49815

Kinase A inhibitor

RWJ-49815 is a potent bactericidal agent that inhibits the KinA autophosphorylation with IC50 of 1.6 uM.
PC-70093

Roseoflavin

Antibiotic

Roseoflavin is a chemical analog of FMN and riboflavin that has antimicrobial activity.
PC-70018

GSK1322322

Peptide deformylase inhibitor

Lanopepden (GSK1322322) is a novel antibacterial agent that targets bacterial peptide deformylase (PDF), inhibits PDF activity and prevents bacterial protein synthesis.
PC-60091

GSK-656

Mtb LeuRS inhibitor

GSK-656 (Ganfeborole; GSK-3036656, GSK656) is a potent, highly selective,orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
PC-60061

LL-3858 dihydrchloride

Anti-tuberculosis agent

Sudoterb (LL-3858) dihydrchloride is a novel anti-TB agent that has an MIC range of 0.06-0.5 ug/mL.
PC-60060

LL-3858

Anti-tuberculosis agent

Sudoterb (LL-3858, LL3858) is a novel anti-TB agent that has an MIC range of 0.06-0.5 ug/mL.
PC-60037

Delpazolid

Antibiotic

Delpazolid (LCB01-0371) is an oxazolidinone antibiotic that shows good antibacterial activity (MSSA MIC50=1 ug/mL).

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