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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-NITD-564
NITD-564

Chemical Structure : NITD-564

CAS No.: 1614262-75-7

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NITD-564 (NITD564)

货号: PC-62532Not For Human Use, Lab Use Only.

NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NITD-564 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.59 uM, exhibits MIC50 of 160 nM against Mtb.
    NITD-564 binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket.
    NITD-564 shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.

    物理化学性质&存储条件

    分子量 283.371
    分子式 C18H21NO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    6-(cyclohexylmethyl)-4-hydroxy-3-phenylpyridin-2(1H)-one

    参考文献

    1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3.

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