Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-63299	Bedaquiline fumarate Mycobacterial ATP synthase inhibitor	Bedaquiline fumarate (R403323, TMC207 fumarate, R207910 fumarate) is a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.
PC-63297	Taniborbactam Beta-lactamase inhibitor	Taniborbactam (VNRX5133) is a highly potent and specific beta-lactamase inhibitor with IC50 of 30 nM, 32 nM, 42 nM, 20 nM for KPC-2, AmpC, OXA-48, and VIM-2 respectively.
PC-63264	RNPA2000 RnpA inhibitor	RNPA2000 is a small-molecule inhibitor of Staphylococcus aureus RnpA-mediated RNA turnover and tRNA processing (IC50=130 uM).
PC-43413	Rifaximin Antibacterial	Rifaximin is an oral, semi-synthetic antibiotic derived from Rifamycin SV with antibacterial activity, interferes with transcription by binding to the β-subunit of bacterial RNA polymerase.
PC-43233	RNPA1000 S. aureus RnpA inhibitor	RNPA1000 is a potent, specific small molecule inhibitor of S. aureus RnpA RNA degradation activity (IC50=100-125 uM), limits S. aureus mRNA turnover and growth.
PC-43057	TBA-354 Antitubercular agent	TBA-354 is a novel antitubercular agent that shows MIC of 6 uM against M. tuberculosis H37Rv.
PC-43054	Epetraborole hydrochloride LeuRS inhibitor	Epetraborole hydrochloride (GSK2251052, AN3365) is a broad-spectrum antibacterial inhibitor of leucyl tRNA-synthetase (LeuRS), shows MIC50/MIC90 of 2/4 ug/ml against 916 clinical anaerobic isolates.
PC-62904	Faropenem Beta-lactam antibiotic	Faropenem is an orally active beta-lactam antibiotic with broad-spectrum antibacterial activity against many gram-positive and gram-negative aerobes and anaerobes.
PC-62903	Imipenem Beta-lactam antibiotic	Imipenem (MK-0787) is a broad-spectrum, semi-synthetic beta-lactam carbapenem that has broad antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.
PC-62849	Pactamycin Antibiotic	Pactamycin (NSC 52947) is a potent protein synthesis inhibitor, inhibits protein synthesis at the translocation step on the 70S ribosome, has activity against Gram-positive and Gram-negative bacteria, and broad antitumor, antiviral, and antiplasmodial activity.
PC-62662	6-FABA Mtb tryptophan synthesis inhibitor	6-FABA (6-Fluoroanthranilic Acid) is a small-molecule inhibitor of MTB tryptophan synthesis that converts Mtb into a tryptophan auxotroph and restores the efficacy of a failed host defense.
PC-62655	3-Cyanochromone WcbL inhibitor	3-Cyanochromone is a potent gram-negative bacteria WcbL protein inhibitor with IC50 of 28 uM in a competitive enzyme-inhibition model, shows inhibition constants Ki of 10 uM.

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