PKZ18

Chemical Structure : PKZ18

CAS No.: 849658-87-3

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货号: PC-38553Not For Human Use, Lab Use Only.

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5 mg	￥2480	In stock
10 mg	￥3880	In stock
25 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

PKZ18 is a small-molecule antibiotic inhibiting the in vivo transcription of glycyl-tRNA synthetase mRNA in gram-positive bacteria, aslo inhibits in vivo translation of the S. aureus threonyl-tRNA synthetase protein.
PKZ8 has MIC value of 32 to 64 μg/ml against most Gram-positive bacteria.
PKZ18 bound to the the GlyQS specifier Loop in vitro with Kd of 24 uM.
PKZ18 targets the site of the codon-anticodon interaction of the conserved stem I and reduces T-box-controlled gene expression.

物理化学性质&存储条件

分子量	398.521
分子式	C22H26N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1s,2r,3s,4r)-3-((4-(4-Isopropylphenyl)-5-methylthiazol-2-yl)carbamoyl)bicyclo[2.2.1]heptane-2-carboxylic acid

参考文献

1. Frohlich KM, et al. ChemMedChem. 2019 Apr 3;14(7):758-769.

2. Väre VYP, et al. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01247-20.

PKZ18

生物&药学活性

物理化学性质&存储条件

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PKZ18

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