PKZ18-22

Chemical Structure : PKZ18-22

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货号: PC-38554Not For Human Use, Lab Use Only.

PKZ18-22 is a potency improved analog of PKZ18, inhibitiong tRNA-regulated gene expression of gram-positive bacteria, shows MIC value of 8 ug/mL against S. aureus.

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生物&药学活性

PKZ18-22 is a potency improved analog of PKZ18, inhibitiong tRNA-regulated gene expression of gram-positive bacteria, shows MIC value of 8 ug/mL against S. aureus.
PKZ18-22 inhibited T-box-controlled expression of glyQS in the glycine auxotroph B. subtilis 1A5, with increasing concentrations showing increased termination of read-through by reverse transcription-quantitative PCR (qRT-PCR).
PKZ18-22 showed no cytotoxicity against eukaryotic cells and significantly lowered the effective dose of gentamicin.

物理化学性质&存储条件

分子量	398.521
分子式	C22H26N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,2R,3S,4R)-3-((4-(4-isobutylphenyl)thiazol-2-yl)carbamoyl)bicyclo[2.2.1]heptane-2-carboxylic acid

参考文献

1. Väre VYP, et al. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01247-20.

PKZ18-22

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PKZ18-22

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物理化学性质&存储条件

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