LFF-571 | Bactericidal antibiotic | Probechem Biochemicals

Chemical Structure : LFF-571

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LFF-571 (LFF571)

货号: PC-38363Not For Human Use, Lab Use Only.

LFF571 is a semisynthetic thiopeptide and bactericidal antibiotic that interferes with bacterial protein synthesis by inhibition of elongation factor EF-Tu, LFF571 is potent in vitro activity against C.difficile strains with MIC90 of 0.25 ug/mL.

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生物&药学活性

LFF571 is a semisynthetic thiopeptide and bactericidal antibiotic that interferes with bacterial protein synthesis by inhibition of elongation factor EF-Tu, LFF571 is potent in vitro activity against C.difficile strains with MIC90 of 0.25 ug/mL.
LFF571 demonstrated activity against most other Gram-positive rods and cocci (MIC50/90, 0.125/0.25 μg/mL) except for bifidobacteria and some species of lactobacilli, showed reduced active activity against Gram-negative anaerobes with MICs for Bacteroides fragilis of 4 and 8 μg/mL.
LFF571 inhibits exogenous protein synthesis elongation factor EF-Tu and interferes with the ability for EF-Tu to deliver aminoacylated tRNA to the ribosome.

物理化学性质&存储条件

分子量	1366.61
分子式	C60H63N13O13S6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. LaMarche MJ, et al. J Med Chem. 2012 Mar 8;55(5):2376-87.

2. Trzasko A, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4459-62.

3. Leeds JA, et al. Antimicrob Agents Chemother. 2012 Aug;56(8):4463-5.

LFF-571 (LFF571)

生物&药学活性

物理化学性质&存储条件

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LFF-571 (LFF571)

生物&药学活性

物理化学性质&存储条件

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