欢迎访问ProbeChem中文网站,英文网站请访问www.probechem.com

首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-22835

Cefiderocol

Antibiotic

Cefiderocol (CFDC, S-649266) is a siderophore cephalosporin antibiotic, has a potent activity against a broad range of aerobic Gram-negative bacterial species with MIC50 of <2 ug/mL.
PC-22815

VOMG

M. abscessus inhibitor

VOMG is a small molecule compound active against Mycobacterium abscessus (Mab, MIC=0.25 ug/mL) and other pathogens by inhibiting cell division.
PC-22813

TST1N-224

S. aureus VraRC inhibitor

TST1N-224 is a potent inhibitor targeting the response regulator VraRC of S. aureus, inhibits the formation of the VraRC-DNA complex with IC50 of 60.2 uM, shows strong binding to VraRC (KD=23.4 uM), enhances the susceptibility of vancomycin-intermediate S. aureus (VISA) to both vancomycin and methicillin.
PC-22725

Kanamycin sulfate

Antibiotic

Kanamycin (Kanamycin A) sulfate is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit.
PC-22724

Kanamycin

Antibiotic

Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit.
PC-22717

PQD-1

DHFR inhibitor

PQD-1 is a DHFR inhibitor with activity against Mycobacterium tuberculosis, PQD-1 synergizes with the dihydropteroate synthase (DHPS) inhibitor sulfamethoxazole (SMX).
PC-22699

C10-AMS

AasS inhibitor

C10-AMS is an acyl adenylate mimic and acyl-acyl carrier protein synthetase (AasS, acyl-ACP synthetase) inhibitor with Ki of 0.6 uM, inhibit the AasS-catalyzed loading of fatty acids onto acyl carrier protein (ACP).
PC-22691

Trypyricin 1

Antibacterial

Trypyricin 1 is a broad-spectrum antibacterial with MIC of 0.5 ug/mL for S. aureus MRSA252 (MRSA), membrane fluidizer, re-sensitizes methicillin-resistant MRSA to β-lactam antibiotics both in vitro and in mice.
PC-22663

Trimethoprim

DHFR inhibitor

Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase (DHFR) inhibitor, shows acitvity against a wide range of Gram-positive and Gram-negative aerobic bacteria.
PC-22662

Brodimoprim

DHFR inhibitor

Brodimoprim (Ro 10-5970) is a trimethoprim analogue and orally active dihydrofolate reductase (DHFR) inhibitor, shows acitvity against a wide range of Gram-positive and Gram-negative aerobic bacteria.
PC-22658

KSP-1007

β-lactamase inhibitor

KSP-1007 is a potent, broad-spectrum boronic acid β-lactamase inhibitor, strongly inhibits class A carbapenemase KPCs with Ki app values of 0.836-2.19 nM, inhibits all β-lactamases from classes A, B, C, and D, enhances meropenem against carbapenem-resistant Gram-negative bacteria.
PC-22624

AN2718

KPC-2 inhibitor

AN2718 is a small molecule inhibitor of the catalytic activity of the Klebsiella pneumoniae carbapenemase (KPC-2) enzyme with IC50 of 0.5 uM and ITC Kd of 86.3 nM, exhibit synergistic antimicrobial effect with Meropenem.

Request The Product List

  • *分类名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *国籍:
  • 留言信息:

备案号:沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com