| Cat. No. |
Product Name |
Information |
| PC-38362 |
MGB-BP-3
C. difficile inhibitor
|
MGB-BP-3 is a potent bactericidal antibiotic with a completely novel mode of action, selectively binds to the minor grove of microbial DNA, has the potential for Clostridioides difficile infection (CDI). |
| PC-38361 |
Ibezapolstat
DNA pol IIIC inhibitor
|
Ibezapolstat (ACX-362E) is a potent, selective, first-in-class DNA polymerase IIIC (DNA pol IIIC) inhibitor with IC50 of 51 nM (B. Subtilis pol IIIC), inhibits C. difficile efficiently (MIC50, 2 ug/mL). |
| PC-73439 |
Quabodepistat
DprE1 inhibitor
|
Quabodepistat (OPC-167832) is a highly potent antituberculosis agent with MIC of 0.00024 to 0.002 ug/mL against Mycobacterium tuberculosis, targets DprE1 (IC50=258 nM, recombinant DprE1), an essential enzyme for cell wall biosynthesis. |
| PC-73350 |
PTC-847
Ng RNR inhibitor
|
PTC-847 (PTC847) is a novel orally active inhibitor that exhibits a narrow spectrum of activity against Neisseria gonorrhoeae (N. gonorrhoeae, Ng) including MDR isolates (MIC, 0.05 to 0.1 ug/mL), directly inhibits class Ia ribonucleotide reductase (RNR). |
| PC-73349 |
PTC-672
Ng RNR inhibitor
|
PTC-672 (PTC672) is a novel orally active inhibitor that exhibits a narrow spectrum of activity against Neisseria gonorrhoeae (N. gonorrhoeae, Ng) including MDR isolates (MIC, 0.05 to 0.4 ug/mL), directly inhibits class Ia ribonucleotide reductase (RNR). |
| PC-73346 |
Xeruborbactam
β-lactamase inhibitor
|
Xeruborbactam (QPX7728) is an ultrabroad-spectrum beta-lactamase inhibitor, inhibits class A extended-spectrum beta-lactamases with IC50 of 1-3 nM, carbapenemases such as KPC (IC50, 2.9 nM), class C P99 (IC50, 22 nM). |
| PC-73194 |
AX20017
M.tb PknG inhibitor
|
AX20017 is a highly selective inhibitor of Mycobacterium tuberculosis protein kinase G (PknG) with IC50 of 0.39 uM. |
| PC-73144 |
Avibactam sodium
β-lactamase inhibitor, ZDHHC3 inhibitor
|
Avibactam sodium (NXL104) is a covalent and reversible non-β-lactam β-lactamase inhibitor with IC50 of 8 nM and 5 nM for β-lactamase TEM-1 and CTX-M-15, respectively, also is a specific inhibitor of ZDHHC3 with Kd of 1.09 uM (MST assay). |
| PC-73118 |
Burkfloxacin
Burkholderia inhibitor
|
Burkfloxacin (BFX) is a fluoroquinolone analog that potently inhibits growth of intracellular Burkholderia. |
| PC-73116 |
DNA gyrase inhibitor EN-7
Bacterial DNA gyrase inhibitor
|
DNA gyrase inhibitor EN-7 (EN-7) is a potent bacterial DNA gyrase inhibitor, is active against pathogenic species that are resistant to ciprofloxacin and other clinically important antibiotics. |
| PC-73075 |
GC-072
Bacterial Topo inhibitor
|
GC-072 (GC072) is a potent, 4-oxoquinolizine antibiotic with selective inhibitory activity against bacterial topoisomerases (E. coli Topo II/DNA gyrase, IC50=0.18-1.5 uM). |
| PC-73074 |
NPG9
SaNSR inhibitor
|
NPG9 (NSR inhibitor NPG9) is a small molecule inhibitor of streptococcus agalactiae nisin resistance protein (NSR) with 58% inhibition at 100 uM (specific growth inhibition assay). |
