Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-73346	Xeruborbactam β-lactamase inhibitor	Xeruborbactam (QPX7728) is an ultrabroad-spectrum beta-lactamase inhibitor, inhibits class A extended-spectrum beta-lactamases with IC50 of 1-3 nM, carbapenemases such as KPC (IC50, 2.9 nM), class C P99 (IC50, 22 nM).
PC-73194	AX20017 M.tb PknG inhibitor	AX20017 is a highly selective inhibitor of Mycobacterium tuberculosis protein kinase G (PknG) with IC50 of 0.39 uM.
PC-73118	Burkfloxacin Burkholderia inhibitor	Burkfloxacin (BFX) is a fluoroquinolone analog that potently inhibits growth of intracellular Burkholderia.
PC-73116	DNA gyrase inhibitor EN-7 Bacterial DNA gyrase inhibitor	DNA gyrase inhibitor EN-7 (EN-7) is a potent bacterial DNA gyrase inhibitor, is active against pathogenic species that are resistant to ciprofloxacin and other clinically important antibiotics.
PC-73075	GC-072 Bacterial Topo inhibitor	GC-072 (GC072) is a potent, 4-oxoquinolizine antibiotic with selective inhibitory activity against bacterial topoisomerases (E. coli Topo II/DNA gyrase, IC50=0.18-1.5 uM).
PC-73074	NPG9 SaNSR inhibitor	NPG9 (NSR inhibitor NPG9) is a small molecule inhibitor of streptococcus agalactiae nisin resistance protein (NSR) with 58% inhibition at 100 uM (specific growth inhibition assay).
PC-72981	CBR490 Anti-Wolbachia	CBR490 (CBR-490) is a potent and selective antiwolbachial activity compound (Anti-Wolbachia wMel In vitro HCI cell-based assay IC50=33 nM, IC90=283 nM).
PC-72980	CBR417 Anti-Wolbachia	CBR417 (CBR-417) is a potent and selective antiwolbachial activity compound (Anti-Wolbachia wMel In vitro HCI cell-based assay IC50=21 nM, IC90=1640 nM).
PC-72874	mCLB073 Rv1625c agonist	mCLB073 (mCLB 073) is a more potent, specific, oral small molecule agonist of the Mtb adenylyl cyclase Rv1625c, an optimized analog of the V-59 for in vivo use.
PC-72873	Rv1625c agonist V-59 Rv1625c agonist	Rv1625c agonist V-59 (V-59) is a specific small molecule agonist of the Mtb adenylyl cyclase Rv1625c, inhibits Mtb growth in macrophages (EC50=0.3 uM) in an Rv1625c-dependent mechanism.
PC-72860	JCP276 Serine hydrolase inhibitor	JCP276 is a novel antibiotic and covalent inhibitor that disrupt M. tuberculosis growth by targeting multiple serine hydrolases.
PC-72815	MBL inhibitor 58 Metallo-β-lactamase inhibitor	MBL inhibitor 58 (InCs compound 58) is a potent broad-spectrum metallo-β-lactamase (MBL inhibitor), active against all MBL classes of major clinical relevance

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