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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-SMARt751
SMARt751

Chemical Structure : SMARt751

CAS No.: 1616370-52-5

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SMARt751 (SMARt-751)

货号: PC-38634Not For Human Use, Lab Use Only.

SMARt751 is a small molecule that interacts with the transcriptional regulator VirS of M. tuberculosis, up-regulates expression of the mymA operon, reverses resistance to ethionamide both in vitro and in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SMARt751 is a small molecule that interacts with the transcriptional regulator VirS of M. tuberculosis, up-regulates expression of the mymA operon, reverses resistance to ethionamide both in vitro and in vivo.
    M.tb transcriptional regulator VirS regulates the mymA operon encoding a monooxygenase that activates ethionamide.
    SMARt751 boosted the efficacy of ethionamide in vitro and in mouse models of acute and chronic TB.
    SMARt751 also restored full efficacy of ethionamide in mice infected with M. tuberculosis strains carrying mutations in the ethA gene, which cause ethionamide resistance in the clinic.

    物理化学性质&存储条件

    分子量 303.301
    分子式 C15H17F4NO
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4,4,4-trifluoro-1-(4-(4-fluorophenyl)piperidin-1-yl)butan-1-one

    参考文献

    1. Marion Flipo, et al. Sci Transl Med. 2022 May 4;14(643):eaaz6280.

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