DU011 | MprA inhibitor | Probechem Biochemicals

Chemical Structure : DU011

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DU011 (DU 011)

货号: PC-38560Not For Human Use, Lab Use Only.

DU011 is a noncanonical anti-infective agent and small-molecule inhibitor of capsule biogenesis, targets MprA (Kd=30 nM), a MarR family transcriptional repressor of multidrug efflux pumps, inhibits capsule expression in E. coli.

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生物&药学活性

DU011 is a noncanonical anti-infective agent and small-molecule inhibitor of capsule biogenesis, targets MprA (Kd=30 nM), a MarR family transcriptional repressor of multidrug efflux pumps, inhibits capsule expression in E. coli.
DU011 does not alter Escherichia coli antibiotic resistance and has significantly enhanced inhibition of capsule expression, compared with other proposed MprA ligands, such as salicylate and 2,4-dinitrophenol (DNP).

物理化学性质&存储条件

分子量	403.400
分子式	C20H15F2NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(2,6-difluorobenzamido)-5-(4-ethoxyphenyl)thiophene-2-carboxylic acid

参考文献

1. Arshad M, et al. Antimicrob Agents Chemother. 2020 Dec 16;65(1):e01208-20.

DU011 (DU 011)

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物理化学性质&存储条件

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DU011 (DU 011)

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物理化学性质&存储条件

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