Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-24195	Xeruborbactam disodium Beta-lactamase inhibitor	Xeruborbactam (QPX7728) disodium is an ultrabroad-spectrum beta-lactamase inhibitor, inhibits class A extended-spectrum beta-lactamases with IC50 of 1-3 nM, carbapenemases such as KPC (IC50, 2.9 nM), class C P99 (IC50, 22 nM).
PC-24194	Xeruborbactam isoboxil Beta-lactamase inhibitor	Xeruborbactam isoboxil is the prodrug of xeruborbactam, an ultrabroad-spectrum beta-lactamase inhibitor, inhibits class A extended-spectrum beta-lactamases with IC50 of 1-3 nM, carbapenemases such as KPC (IC50, 2.9 nM), class C P99 (IC50, 22 nM).
PC-24024	MraY inhibitor 12a MraY inhibitor	MraY inhibitor 12a is a first-in-class, non-nucleoside inhibitor of bacterial enzyme MraY with IC50 of 25 uM, exhibits broad-spectrum antibacterial activity.
PC-23990	Enoxacin DNA Gyrase inhibitor	Enoxacin (Enoxacin sesquihydrate) is a fluoroquinolone antibiotic, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml). Enoxacin is a miRNA processing activator and enhances siRNA-mediated mRNA degradation and promotes the biogenesis of endogenous miRNAs. Enoxacin shows potent activities against gram-positive and -negative bacteria. Enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-bi
PC-23989	Enoxacin hydrate DNA Gyrase inhibitor	Enoxacin hydrate (Enoxacin sesquihydrate) is a fluoroquinolone antibiotic, interferes with DNA replication and inhibits bacterial DNA gyrase (IC50=126 µg/ml) and topoisomerase IV (IC50=26.5 µg/ml).
PC-23925	V-161 EhV-ATPase inhibitor	V-161 is a potent, specific E. hirae Na+-transporting V-ATPase (EhV-ATPase) inhibitor with IC50 of 144 nM, blocks the function of Na+-transporting V-ATPase and preferentially inhibits the growth of enterococci.
PC-23867	BRD1401 OprH-LPS inhibitor	BRD1401 is a P. aeruginosa-specific inhibitor targeting outer membrane protein OprH-LPS interaction, increases membrane fluidity.
PC-23837	Mycobactin 1400-46-0	Mycobactin (Mycobactin M) is a conditionally essential molecule expressed by mycobacteria in iron-stress conditions.
PC-23818	Bio-AMS Biotin protein ligase inhibitor	Bio-AMS is a potent bacterial biotin protein ligase (BPL) inhibitor, possesses selective activity against Mycobacterium tuberculosis (Mtb) and inhibits fatty acid and lipid biosynthesis.
PC-23766	MtbFadD32 inhibitor M1 Mtb FadD32 inhibitor	MtbFadD32 inhibitor M1 is a small molecule inhibitor of Mycobacterium tuberculosis fatty acyl-AMP ligase FadD32 and FadD28, shows specific antitubercular activity with IC50 of 4.8 ug/mL, binds and inhibits the FAAL activity of MtbFadD32 and MtbFadD28 enzymes.
PC-23757	STK848198 FtsH inhibitor	STK848198 is a small molecule antimicrobial compound with MIC of 2 ug/mL against S. aureus by targeting ATP‐binding protein FtsH, inhibits methicillin‐sensitive S. aureus, MSRA, VAN intermediate S. aureus (VISA), and DAP‐resistant strains with MIC ranged from 0.5 to 8 ug/mL.
PC-23656	Evybactin M.tb DNA gyrase inhibitor	Evybactin is a potent and selective antibiotic acting against M. tuberculosis (MIC=0.25 ug/mL) targeting DNA gyrase.

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