| Cat. No. |
Product Name |
Information |
| PC-24816 |
DRILS-1398
M.tb chorismate mutase inhibitor
|
DRILS-1398 is a potent inhibitor of M.tb chorismate mutase (M.tb-CM) with IC50 of 3.0 uM, demonstrates efficacy against multi-drug resistant M.tb strains (MIC=4 ug/mL), inhibits M.tb amino acid biosynthetic pathway. |
| PC-24738 |
Tarocin B
TarO inhibitor
|
Tarocin B is a specific inhibitor of UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (TarO) with IC50 of 0.41 uM, inhibits the first step in wall teichoic acid biosynthesis, restore β-lactam efficacy against MRSA. |
| PC-24737 |
Tarocin A
TarO inhibitor
|
Tarocin A is a specific inhibitor of UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (TarO) with IC50 of 0.18 uM, inhibits the first step in wall teichoic acid biosynthesis, restore β-lactam efficacy against MRSA. |
| PC-24471 |
TU-514
LpxC inhibitor
|
TU-514 is a substrate-analog inhibitor of zinc-dependent UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) with Ki of 3.9 uM for E. coli LpxC and IC50 of 7.0 uM (A. aeolicus LpxC) |
| PC-24470 |
L-573655
LpxC inhibitor
|
L-573655 (L-573,655) is a specific small molecule inhibitor of UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC), inhibits E. coli LpxC with Ki values of 24 uM and approximately 50 nM, respectively. |
| PC-24466 |
JSF-4536
M.tb MenG inhibitor
|
JSF-4536 is a small molecule inhibitor of Mycobacterium tuberculosis methyltransferase MenG enzyme, inhibits menaquinone biosynthetic pathway, inhibits M. tuberculosis H37Rv strain with MIC of 0.78 uM. |
| PC-24465 |
JSF-4898
M.tb MenG inhibitor
|
JSF-4898 is a small molecule inhibitor of Mycobacterium tuberculosis methyltransferase MenG enzyme, inhibits menaquinone biosynthetic pathway, inhibits M. tuberculosis H37Rv strain with MIC of 0.78 uM. |
| PC-24460 |
IP6C
Type II Thoeris system inhibitor
|
IP6C is a small molecule inhibitor of type II Thoeris systems encoded by multiple bacteria species, inhibits BaY2 Thoeris with IC50 of 10 uM, inhibits the type II Thoeris system by blocking His-ADPR production by ThsB. |
| PC-24403 |
HilD inhibitor C26
S. Typhimurium HilD inhibitor
|
HilD inhibitor C26 is a specific small molecule inhibitor of S. Typhimurium transcriptional regulator HilD with IC50 of 16.9 uM and binds to HilD with an apparent Kd of 30.2 uM, inhibits the secretion of SipA with IC50 of 29.2 uM. |
| PC-24393 |
FG-2101
LpxC inhibitor
|
FG-2101 (FG2101) is a potent, in vivo active, non-hydroxamate inhibitor of LpxC with IC50 of 1 nM, exhibits exquisite selectivity over other bacterial and human metalloenzymes (>10,000-fold). |
| PC-24388 |
MBX-4132
Trans-translation inhibitor
|
MBX-4132 is a trans-translation inhibitor with IC50 of 0.6 uM and 0.4 uM in E. coli luciferase reporter assay and in vitro reconstituted assays respectively, exhibits potent broad-spectrum antibiotic activity against Gram-positive species and many Gram-negative species. |
| PC-24353 |
H052
S. aureus α-hemolysin inhibitor
|
H052 is a highly potent S. aureus α-hemolysin (Hla) inhibitor, protect U937 cells from Hla-induced Ca2+ influx with EC50 of 0.01 uM, restores Hla-induced damage of host cell integrity. |
