Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-22724	Kanamycin Antibiotic	Kanamycin (Kanamycin A) is an orally active antibacterial (gram-negative/positive bacteria) agent, inhibits translocation and causes misencoding by binding to the 70 S ribosomal subunit.
PC-22717	PQD-1 DHFR inhibitor	PQD-1 is a DHFR inhibitor with activity against Mycobacterium tuberculosis, PQD-1 synergizes with the dihydropteroate synthase (DHPS) inhibitor sulfamethoxazole (SMX).
PC-22699	C10-AMS AasS inhibitor	C10-AMS is an acyl adenylate mimic and acyl-acyl carrier protein synthetase (AasS, acyl-ACP synthetase) inhibitor with Ki of 0.6 uM, inhibit the AasS-catalyzed loading of fatty acids onto acyl carrier protein (ACP).
PC-22691	Trypyricin 1 Antibacterial	Trypyricin 1 is a broad-spectrum antibacterial with MIC of 0.5 ug/mL for S. aureus MRSA252 (MRSA), membrane fluidizer, re-sensitizes methicillin-resistant MRSA to β-lactam antibiotics both in vitro and in mice.
PC-22663	Trimethoprim DHFR inhibitor	Trimethoprim is a bacteriostatic antibiotic and an orally active dihydrofolate reductase (DHFR) inhibitor, shows acitvity against a wide range of Gram-positive and Gram-negative aerobic bacteria.
PC-22662	Brodimoprim DHFR inhibitor	Brodimoprim (Ro 10-5970) is a trimethoprim analogue and orally active dihydrofolate reductase (DHFR) inhibitor, shows acitvity against a wide range of Gram-positive and Gram-negative aerobic bacteria.
PC-22624	AN2718 KPC-2 inhibitor	AN2718 is a small molecule inhibitor of the catalytic activity of the Klebsiella pneumoniae carbapenemase (KPC-2) enzyme with IC50 of 0.5 uM and ITC Kd of 86.3 nM, exhibit synergistic antimicrobial effect with Meropenem.
PC-22567	OXF-077 Antibacterial agent	OXF-077 is a potent inhibitor of the mutagenic SOS response, suppresses the rate of ciprofloxacin resistance emergence in S. aureus, is a potentiator of DNA-damage in MRSA.
PC-22557	Ciprofloxacin Antibiotic	Ciprofloxacin (Bay-09867) is a potent, orally active topoisomerase IV inhibitor and fluoroquinolone antibiotic, induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production.
PC-22556	LEI-800 Bacterial DNA gyrase inhibitor	LEI-800 is potent antibacterial as an allosteric bacterial topoisomerase DNA gyrase inhibitor with MIC of 3.1 uM and 6.25 uM for E. coli and K. pneumoniae respectively, inhibits the ATP-dependent supercoiling activity of recombinant E. coli DNA gyrase in a gel-based assay with IC50 of 35 nM.
PC-22548	D8-03 Francisella tularensis inhibitor	D8-03 is a potent inhibitor of intracellular growth of Francisella tularensis with IC50 of 15 nM in CFU assays, MIC50 value of 0.39 uM.
PC-22508	ECIN (E. coli inhibitor) UPEC inhibitor	ECIN (E. coli inhibitor) is a copper-responsive small molecule inhibitor of wild-type uropathogenic Escherichia coli (UPEC) strains with IC50 of 336 ng/mL in the absence of copper, and 260 and 128 ng/mL in the presence of 25 and 250 µM copper, respectively.

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