FBX-1991 | H. pylori FabX inhibitor | Probechem Biochemicals

Chemical Structure : FBX-1991

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FBX-1991 (FBX1991)

货号: PC-24236Not For Human Use, Lab Use Only.

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生物&药学活性

FBX-1991 is a potent, specific small molecule inhibitor of Helicobacter pylori (H. pylori) dehydrogenase/isomerase FabX with IC50 of 0.158 uM, shows potent antibacterial activity against strain BHKS211 with MIC of 16 ug/mL.
FabX is essential for H. pylori growth and gastric colonization by retaining UFA synthesis and producing ROS, respectively, and is a species-specific anti-H. pylori drug target.
FBX-1991 does not inhibit the enzymatic activities of the structurally conserved homolog FabK.
FBX-1991 significantly inhibits the growth of H. pylori strain G27 and three clinical drug-resistant isolates with MIC of 16 ug/mL, but does not inhibit the growth of the non-Helicobacter strains at 128 ug/mL.
FBX-1991 partially inhibits UFA and cyclopropane fatty acid synthesis, ROS production and subsequent excretion from H. pylori by specifically targeting FabX in vivo.

物理化学性质&存储条件

分子量	452.31
分子式	C19H15Cl2N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 3-((2-((2,4-dichlorophenyl)amino)pyridine)-3-sulfonamido)benzoate

参考文献

1. Zhang L, et al. Adv Sci (Weinh). 2025 Mar 16:e2414844.

FBX-1991 (FBX1991)

生物&药学活性

物理化学性质&存储条件

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FBX-1991 (FBX1991)

生物&药学活性

物理化学性质&存储条件

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