欢迎访问ProbeChem中文网站,英文网站请访问www.probechem.com

首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-61930

Beauvericin

Antibacterial

Beauvericin is a cyclic hexadepsipeptide with antibiotic and insecticidal effects, shows activity against Gram-positive bacteria and mycobacteria, and is also capable of inducing programmed cell death in mammals.
PC-61788

SPI009

P. aeruginosa inhibitor

SPI009 is a novel antipersister compound active against P. aeruginosa.
PC-61783

Inh2-B1

STK1 inhibitor

Inh2-B1 (STK1 inhibitor B1) is a novel specific S aureus Ser/Thr protein kinase (STK1) inhibitor with IC50 of 49 uM, directly binds to ATP-binding catalytic domain.
PC-61756

NITD-304

MmpL3 inhibitor

NITD-304 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 15 nM against M tuberculosis H37Rv.
PC-61755

NITD-349

MmpL3 inhibitor

NITD-349 is a novel, orally bioavailable mycobacterial membrane protein Large 3 (MmpL3) inhibitor with MIC of 23 nM against M tuberculosis H37Rv.
PC-61754

BM635

MmpL3 inhibitor

BM635 is a small molecule anti-mycobacterial compound acting by inhibiting the mycobacterial membrane protein Large 3 (MmpL3).
PC-61751

AU-1235

MmpL3 inhibitor

AU-1235 is a novel, specific mycobacterial membrane protein large 3 (MmpL3) inhibitor with MIC of 0.1 ug/mL (0.3 uM) against Mtb H37Rv..
PC-61750

MmpL3 inhibitor C215

MmpL3 inhibitor

C215 is a novel inhibitor of mycobacterial membrane protein large 3 (MmpL3) with MIC90 of 16 uM against M. tuberculosis.
PC-61436

CRS3123

MetRS inhibitor

CRS3123 (REP 3123) is a novel diaryldiamine that inhibits bacterial methionyl-tRNA synthetases (MetRS) in Gram-positive bacteria as a novel agent to treat Clostridium difficile infection (CDI).
PC-61388

Macozinone

DprE1 inhibitor

Macozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
PC-61371

Contezolid

Antibiotic

Contezolid (MRX I) is an orally active oxazolidinone agent with antibacterial activity Gram-positive pathogens, including MRSA, penicillin-PRSP, PISP, and vancomycin-resistant enterococci (VRE) with MIC of 0.25-4 ug/mL.
PC-61295

Murepavadin

Antibiotic, MRGPRX2 agonist

Murepavadin (POL7080) is a highly potent, specific, macrocycle Pseudomonas antibiotic, activates mast cells via MRGPRX2 and MrgprB2.

Request The Product List

  • *分类名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *国籍:
  • 留言信息:

备案号:沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com