Compound 11626252

Chemical Structure : Compound 11626252

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货号: PC-72403Not For Human Use, Lab Use Only.

Compound 11626252 is a potent, specific antitubercular agent against Mycobacterium tuberculosis (M. tb) with MIC of 0.02 ug/mL, targets cytochrome bc1 complex.

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生物&药学活性

Compound 11626252 is a potent, specific antitubercular agent against Mycobacterium tuberculosis (M. tb) with MIC of 0.02 ug/mL, targets cytochrome bc1 complex.
Compound 11626252 demonstrated ex vivo activity in THP-1 macrophages infected with M.tb H37Rv with IC50 of 0.011 ug/mL.
Compound 11626252 showed no activity against DS- and DR-members of the M. tb complex (MTBC), as well as against their close relative, M. marinum.
The mutation in QcrA (L356V) is responsible for resistance to Compound 11626252.

物理化学性质&存储条件

分子量	237.296
分子式	C11H12FN3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(ethylthio)-8-fluoro-N-methylquinazolin-4-amine

参考文献

1. Andréanne Lupien, et al. PLoS Pathog. 2020 Jan 23;16(1):e1008270.