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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-FIM1033
FIM1033

Chemical Structure : FIM1033

CAS No.: 2018335-58-3

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FIM1033 (FIM-1033)

货号: PC-72410Not For Human Use, Lab Use Only.

FIM1033 (FIM-1033) is a potent small-molecule inhibitor of FimH with HAI EC90 of 8 nM, with antibiotica activities, significantly attenuated bacterial loads in pyelonephritis in treated mice.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    FIM1033 (FIM-1033) is a potent small-molecule inhibitor of FimH with HAI EC90 of 8 nM, with antibiotica activities, significantly attenuated bacterial loads in pyelonephritis in treated mice.

    物理化学性质&存储条件

    分子量 429.469
    分子式 C23H27NO7
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    Chemical Name/SMILES

    7-(4-((1R)-hydroxy((3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)methyl)-3-methylphenyl)-3,4-dihydroisoquinolin-1(2H)-one

    参考文献

    1. Lisa K McLellan, et al. PLoS Pathog. 2021 Jan 29;17(1):e1009314.

    2. Laurel Mydock-McGrane, et al. J Med Chem. 2016 Oct 27;59(20):9390-9408.

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