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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-KYT-36
KYT-36

Chemical Structure : KYT-36

CAS No.: 454473-31-5

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KYT-36 (KYT36)

货号: PC-72419Not For Human Use, Lab Use Only.

KYT-36 is a potent, selective, and bioavailable inhibitor of P. gingivalis virulence factor gingipain K (Kgp, lysine-gingipain), potently and selectively inhibits Kgp with Ki of 0.27 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    KYT-36 is a potent, selective, and bioavailable inhibitor of P. gingivalis virulence factor gingipain K (Kgp, lysine-gingipain), potently and selectively inhibits Kgp with Ki of 0.27 nM, respectively.
    KYT-36 consists of benzyloxycarbonyl (BOC), L-glutaminyl (GLN), methylphenylamino (MPA), L-lysinyl (LYS), and benzylcarbamoyl (BCA) moieties.
    KYT-36 strongly inhibited degradation of host proteins in culture supernatants and abolished thriving of P. gingivalis in cell cultures and in periodontal pockets in vivo.
    KYT-36 prevented Kgp-triggered vascular permeability in guinea pigs, i.e. demonstrating its efficacy against bacterial virulence in vivo, with no toxicity effects.

    物理化学性质&存储条件

    分子量 630.746
    分子式 C34H42N6O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    benzyl-N-[(2S)-1-[[(3S)-7-amino-1-(benzylamino)-1,2-dioxoheptan-3-yl]amino]-5-(2-methyl-2-phenylhydrazinyl)-1,5-dioxopentan-2-yl]carbamate dichloride salt

    参考文献

    1. Tibisay Guevara, et al. Sci Rep. 2019; 9: 4935.

    2. Kataoka S, et al. FASEB J. 2014 Aug; 28(8):3564-78.

    3. Kadowaki T, et al. Mol Pharmacol. 2004 Dec;66(6):1599-606.

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