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MRL-494

Chemical Structure : MRL-494

CAS No.: 2434898-43-6

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MRL-494 (MRL494)

货号: PC-72087Not For Human Use, Lab Use Only.

MRL-494 (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MRL-494 (MRL494) is an antimicrobial small molecule that inhibits assembly of outer membrane proteins (OMPs) by the β-barrel assembly machine (BAM complex), inhibits the insertion of OMPs into the OM by targeting BamA.
    MRL-494 exhibited antimicrobial activity against a broad range of bacterial species, impairs biogenesis of OMPs and potentiates rifampicin.
    MRL-494 impairs biogenesis of OMPs, BamAE470K provides resistance to MRL-494 and restores OMP biogenesis.
    MRL-494 inhibits Gram-positive and -negative microbes through distinct mechanisms of action.

    物理化学性质&存储条件

    分子量 622.674
    分子式 C26H35FN16O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-carbamimidoyl-3-cyclopropyl-3-((4-(((1s,4s)-4-(2-(5-(4-fluorophenyl)-2H-tetrazol-2-yl)acetamido)cyclohexyl)amino)-6-guanidino-1,3,5-triazin-2-yl)amino)propanamide

    参考文献

    1. Elizabeth M Hart, et al. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21748-21757.

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