欢迎访问ProbeChem中文网站,英文网站请访问www.probechem.com

首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-21545

MSU-43085

Mtb MmpL3 inhibitor

MSU-43085 is a potent, orally bioavailable inhibitor of Mycobacterium tuberculosis (Mtb, EC50=120 nM) and M. abscessus survival, targets MmpL3.
PC-21529

Inhibitor 21272541

FabI inhibitor

Inhibitor 21272541 is a small molecule inhibitor against the enoyl-acyl carrier protein reductase-FabI protein of Acinetobacter baumannii.
PC-21216

C. difficile inhibitor 57

C. difficile inhibitor

C. difficile inhibitor 57 is a potent, selective, narrow-spectrum antibacterial against Clostridioides difficile with MIC50 of 0.5 ug/mL, targets cell-wall synthesis.
PC-21137

SAV13

SaeR inhibitor

SAV13 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 1.06 uM in luciferase assays, reduces expression of hla and other virulence factors.
PC-21136

HR3744

SaeR inhibitor

HR3744 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 10 uM in saeP1 promoter assays, reduces expression of hla and other virulence factors.
PC-21120

Compound 5-6

FtsW inhibitor

Compound 5-6 (FtsW inhibitor 5-6) is a specific small molecule inhibitor of bacterial cell wall polymerase FtsW, competes with Lipid II for binding to FtsW with Ki of 0.8 uM, has an MIC of 1 μg /mL against S. aureus.
PC-21050

Clovibactin

Antibiotic

Clovibactin is a novel depsipeptide antibiotic, exhibits antibacterial activity against a broad range of Gram-positive pathogens (MIC, 1-2 ug/mL, ATCC 33591 MRSA), Clovibactin targets cell wall biosynthesis.
PC-20704

Min-1

Antibacterial agent

Min-1 is small molecule that inhibits growth of Gram-positive bacteria by targeting the cell envelope, Min-1 is a novel inhibitor of bacterial growth, reduces cell size in Bacillus subtilis.
PC-20696

SK-017154-O

PelA inhibitor

SK-017154-O is a specific and noncompetitive inhibitor of PelA, specifically inhibits PelA esterase activity with IC50 of 11 uM, inhibits Pel-dependent PA14 biofilms with IC50 of 1.8 uM.
PC-20672

MK-3402

Metallo-beta-lactamase inhibitor

MK-3402 is a small molecule metallo-beta-lactamase inhibitor with antibiotic activity.
PC-20594

Compound 2B5

S. mutans VicR inhibitor

Compound 2B5 is a potent small molecule against S. mutans with IC50 of 1.9 uM, specifically targets the key response regulator VicR (Kd=87 uM) in both S. mutans and S. aureus.
PC-20571

IMP-1700

Bacterial AddAB complex inhibitor

IMP-1700 (IMP1700) is a potent, cell-active inhibitor of bacterial AddAB-mediated DNA repair, sensitizes MRSA to ciprofloxacin (CFX) with an EC50 of 5.9 nM.

Request The Product List

  • *分类名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *国籍:
  • 留言信息:

备案号:沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com