Cat. No. |
Product Name |
Information |
PC-35948 |
GSK3011724A
KasA inhibitor
|
GSK3011724A (DG167, GSK3011724A) is a potent, specific inhibitor of β-ketoacyl-ACP synthase (KasA, Kd=9 nM), shows anti-tubercular activity (MIC H37Rv=0.8 uM). |
PC-35941 |
JSF-4088
Antitubercular agent
|
JSF-4088 (JSF4088) is a novel antitubercular agent with potent in vitro antitubercular potency (MIC=19 nM), with no significant Vero cell cytotoxicity (CC50 >120 uM). |
PC-35875 |
QcrB inhibitor TB47
QcrB inhibitor
|
QcrB inhibitor TB47 (TB47) is a novel antimycobacterial agent that fuctions as a putative respiratory complex III (QcrB) inhibitor with MIC of 0.016-0.5 ug/mL against a panel of 56 M. tuberculosis clinical isolates. |
PC-35872 |
D13-9001
MexAB-OprM inhibitor
|
D13-9001 (D 13-9001) is a small molecule, MexAB-OprM specific efflux pump inhibitor with good potency in vitro (MPC 2 ug/mL) and displays excellent activity in vivo in a rat pneumonia model of P. aeruginosa. |
PC-35825 |
Lethal toxin inhibitor DN1
|
Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280 uM, respectively. |
PC-35818 |
FtsZ inhibitor C109
FtsZ inhibitor
|
FtsZ inhibitor C109 (Compound 10126109) is a broad spectrum antibacterial compound that inhibits the cell division protein FtsZ, inhibits the FtsZ GTPase activity with IC50 of 8.2 uM. |
PC-35816 |
AgrA inhibitor F19
AgrA inhibitor
|
AgrA inhibitor F19 is a small-molecule AgrA inhibitor that act as antivirulence agent against Gram-positive pathogens, blocks staphylococcal transcription factor AgrA from binding to its promoter and inhibits toxin and virulence factor transcription. |
PC-35771 |
SIG1459
Antibacterial, TLR2 inhibitor
|
SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling. |
PC-43542 |
Finafloxacin
Antibiotic
|
Finafloxacin is a fluoroquinolone antibiotic that demonstrates superior activity to ciprofloxacin under acidic conditions (pH5.8, A. baumannii isolates MIC=0.03-0.12ug/mL). |
PC-35447 |
Durlobactam
β-lactamase inhibitor
|
Durlobactam (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A β-lactamase KPC-2, class AmpC and class D OXA-24, respectively. |
PC-35421 |
ClpP inhibitor M21
ClpP inhibitor
|
ClpP inhibitor M21 is a noncompetitive inhibitor of ClpP with IC50 of 41.42 uM, inhibits ClpP cleavage of SUc-LY-AMC substrate in a peptidase assay. |
PC-35372 |
NOSO-502
Bacterial translation inhibitor
|
NOSO-502 (NOSO502) is a novel inhibitor of bacterial translation, has MIC values of 0.5-4 ug/ml against standard Enterobacteriaceae strains and carbapenem-resistant Enterobacteriaceae (CRE) isolates that produce KPC, AmpC, or OXA enzymes and metallo-β-lactamases. |