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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Quabodepistat
Quabodepistat

Chemical Structure : Quabodepistat

CAS No.: 1883747-71-4

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Quabodepistat (OPC-167832, OPC167832)

货号: PC-73439Not For Human Use, Lab Use Only.

Quabodepistat (OPC-167832) is a highly potent antituberculosis agent with MIC of 0.00024 to 0.002 ug/mL against Mycobacterium tuberculosis, targets DprE1 (IC50=258 nM, recombinant DprE1), an essential enzyme for cell wall biosynthesis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Quabodepistat (OPC-167832) is a highly potent antituberculosis agent with MIC of 0.00024 to 0.002 ug/mL against Mycobacterium tuberculosis, targets DprE1 (IC50=258 nM, recombinant DprE1), an essential enzyme for cell wall biosynthesis.
    OPC-167832 showed MIC90 of 0.0048 and 0.0027 ug/mL against intracellular M. tuberculosis strains H37Rv and Kurono were 0.0048 and 0.0027, respectively.
    OPC-167832 showed potent bactericidal activities starting at a dose of 0.625 mg/kg of body weight in a mouse model of chronic TB.
    OPC-167832 exhibited significant combination effects in 2-drug combinations with delamanid, bedaquiline, or levofloxacin.

    物理化学性质&存储条件

    分子量 456.846
    分子式 C21H20ClF3N2O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2(1H)-Quinolinone, 5-[[(3R,4R)-1-(4-chloro-2,6-difluorophenyl)-3,4-dihydroxy-4-piperidinyl]methoxy]-8-fluoro-3,4-dihydro-

    参考文献

    1. Hariguchi N, et al. Antimicrob Agents Chemother. 2020 May 21;64(6):e02020-19.

    2. Robertson GT, et al. Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0058321.

    3. Tasneen R, et al. Antimicrob Agents Chemother. 2022 Mar 22:e0239821.

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