DNA gyrase inhibitor EN-7 | Bacterial DNA gyrase inhibitor

Chemical Structure : DNA gyrase inhibitor EN-7

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DNA gyrase inhibitor EN-7 (EN-7)

货号: PC-73116Not For Human Use, Lab Use Only.

DNA gyrase inhibitor EN-7 (EN-7) is a potent bacterial DNA gyrase inhibitor, is active against pathogenic species that are resistant to ciprofloxacin and other clinically important antibiotics.

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生物&药学活性

DNA gyrase inhibitor EN-7 (EN-7) is a potent bacterial DNA gyrase inhibitor, is active against pathogenic species that are resistant to ciprofloxacin and other clinically important antibiotics.
EN-7 inhibited growth of the wild-type strain (S. aureus) with MIC 1 μM.
Strains containing GyrA A34T (mut-3 and mut-9), GyrA P219Q (mut-6), and GyrB K417E (mut-1, mut-2, mut-4, and mut-5) exhibited moderate resistance, with MICs of either 4 or 8 μM.
EN-7 inhibited sporulation pathway in the bacterial genus Streptomyces.

物理化学性质&存储条件

分子量	384.395
分子式	C22H16N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-5-phenyl-N'-(3-(quinolin-8-yl)acryloyl)isoxazole-3-carbohydrazide

参考文献

1. McAuley S, et al. Cell Chem Biol. 2019 Sep 19;26(9):1274-1282.e4.

DNA gyrase inhibitor EN-7 (EN-7)

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物理化学性质&存储条件

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DNA gyrase inhibitor EN-7 (EN-7)

生物&药学活性

物理化学性质&存储条件

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