Avibactam sodium (NXL104) | β-lactamase inhibitor, ZDHHC3 inhibitor

Chemical Structure : Avibactam sodium

CAS No.: 1192491-61-4

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Avibactam sodium (NXL104, NXL-104)

货号: PC-73144Not For Human Use, Lab Use Only.

Avibactam sodium (NXL104) is a covalent and reversible non-β-lactam β-lactamase inhibitor with IC50 of 8 nM and 5 nM for β-lactamase TEM-1 and CTX-M-15, respectively, also is a specific inhibitor of ZDHHC3 with Kd of 1.09 uM (MST assay).

规格	价格	库存
10 mg	￥780	In stock
50 mg	￥1880	In stock
100 mg	￥2980	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

Avibactam sodium (NXL104) is a covalent and reversible non-β-lactam β-lactamase inhibitor with IC50 of 8 nM and 5 nM for β-lactamase TEM-1 and CTX-M-15, respectively, also is a specific inhibitor of ZDHHC3 with Kd of 1.09 uM (MST assay).

Avibactam sodium destabilizes SCAP, reduces SREBP2 transcription, and inhibits HCC growth.

Avibactam sodium inhibits class A and C β-lactamases, but not metallo types and Acinetobacter OXA carbapenemases.

Avibactam sodium also decreases the protein levels of ZDHHC3 and SCAP and liver total cholesterol levels, in a DEN/CCl4-induced mouse model of HCC.

物理化学性质&存储条件

分子量	287.23
分子式	C7H10N3NaO6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	100 mM in H2O
Chemical Name/SMILES	Sodium (1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate

参考文献

1. Ehmann DE, et al. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.
2. Wu M, et al. Cell Rep. 2024 Nov 26;43(11):114962.

Avibactam sodium (NXL104, NXL-104)

生物&药学活性

物理化学性质&存储条件

参考文献

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Avibactam sodium (NXL104, NXL-104)

生物&药学活性

物理化学性质&存储条件

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