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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-MGB-BP-3
MGB-BP-3

Chemical Structure : MGB-BP-3

CAS No.: 1000277-08-6

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MGB-BP-3

货号: PC-38362Not For Human Use, Lab Use Only.

MGB-BP-3 is a potent bactericidal antibiotic with a completely novel mode of action, selectively binds to the minor grove of microbial DNA, has the potential for Clostridioides difficile infection (CDI).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MGB-BP-3 is a potent bactericidal antibiotic with a completely novel mode of action, selectively binds to the minor grove of microbial DNA, has the potential for Clostridioides difficile infection (CDI).

    物理化学性质&存储条件

    分子量 631.737
    分子式 C36H37N7O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-1-methyl-4-(1-methyl-4-(4-(2-(quinolin-3-yl)vinyl)benzamido)-1H-pyrrole-2-carboxamido)-N-(2-morpholinoethyl)-1H-pyrrole-2-carboxamide

    参考文献

    1. Louie T, et al. Phase IIa Dose Escalation Treatment of Clostridioides Difficile-Associated Diarrhea with MGB-BP-3, a Novel First in Class DNA Minor Grove Binding Antibiotic. ECCMID; 2020.

    2. Ravina Kullar, et al. J Exp Pharmacol. 2020 Oct 9;12:371-384.

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