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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Ibezapolstat
Ibezapolstat

Chemical Structure : Ibezapolstat

CAS No.: 1275582-97-2

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Ibezapolstat (ACX-362E, GLS-362E)

货号: PC-38361Not For Human Use, Lab Use Only.

Ibezapolstat (ACX-362E) is a potent, selective, first-in-class DNA polymerase IIIC (DNA pol IIIC) inhibitor with IC50 of 51 nM (B. Subtilis pol IIIC), inhibits C. difficile efficiently (MIC50, 2 ug/mL).

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5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ibezapolstat (ACX-362E) is a potent, selective, first-in-class DNA polymerase IIIC (DNA pol IIIC) inhibitor with IC50 of 51 nM (B. Subtilis pol IIIC), inhibits C. difficile efficiently (MIC50, 2 ug/mL).
ACX-362E is a potent inhibitor of diverse clinical isolates of C. difficile with MIC50 of 2 ug/ml and MIC90 of 4 ug/ml.
ACX-362E shows preferential activity against C. difficile PolC over those of other organisms in vitro.
ACX-362E demonstrated therapeutic potential for the oral treatment of Clostridioides difficile infection (CDI).

物理化学性质&存储条件

分子量 423.298
分子式 C18H20Cl2N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((3,4-dichlorobenzyl)amino)-7-(2-morpholinoethyl)-1,7-dihydro-6H-purin-6-one

参考文献

1. van Eijk E, et al. Antimicrob Agents Chemother. 2019 Jan 29;63(2):e01363-18.

2. Xu WC, et al. Bioorg Med Chem. 2019 Aug 1;27(15):3209-3217.

3. Murray B, et al. J Antimicrob Chemother. 2020 Aug 1;75(8):2149-2155.

4. Kullar R, et al. J Exp Pharmacol. 2020 Oct 9;12:371-384.

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