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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-PTC-672
PTC-672

Chemical Structure : PTC-672

CAS No.: 1962140-61-9

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PTC-672 (PTC672)

货号: PC-73349Not For Human Use, Lab Use Only.

PTC-672 (PTC672) is a novel orally active inhibitor that exhibits a narrow spectrum of activity against Neisseria gonorrhoeae (N. gonorrhoeae, Ng) including MDR isolates (MIC, 0.05 to 0.4 ug/mL), directly inhibits class Ia ribonucleotide reductase (RNR).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PTC-672 (PTC672) is a novel orally active inhibitor that exhibits a narrow spectrum of activity against Neisseria gonorrhoeae (N. gonorrhoeae, Ng) including MDR isolates (MIC, 0.05 to 0.4 ug/mL), directly inhibits class Ia ribonucleotide reductase (RNR).
    PTC-672 is inactive against the panel of Gram-negative pathogens and normal gut organism (MICs ranging from 12.5 to ≥62.5 ug/mL).
    PTC-672 demonstrates clear antibiotic activity preference toward all Neisseria species examined including MDR organisms and the Nm M2092 serogroup B (NMSB) reference strain.
    PTC-672 targets DNA synthesis and the class Ia RNR large subunit, but not DNA topoisomerases. PTC-672 showed 78% inhibition at 2.5 μM aginst Ng RNR activity, also inhibits Ec RNR, but does not inhibits human RNR at 100 uM.
    PTC-672 (30 mg/kg) demosntrates in vivo efficacy in a mouse model of gonorrhea.

    物理化学性质&存储条件

    分子量 377.397
    分子式 C18H23N3O6
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-ethyl-7-hydroxy-2-((2-methoxyethoxy)methyl)-9-oxo-3,4,5,6,9,10-hexahydroimidazo[4',5':6,7]cyclohepta[1,2-b]pyridine-8-carboxylic acid

    参考文献

    1. Jana Narasimhan, et al. Elife. 2022 Feb 9;11:e67447.

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