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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-70093

Roseoflavin

Antibiotic

Roseoflavin is a chemical analog of FMN and riboflavin that has antimicrobial activity.
PC-70018

GSK1322322

Peptide deformylase inhibitor

Lanopepden (GSK1322322) is a novel antibacterial agent that targets bacterial peptide deformylase (PDF), inhibits PDF activity and prevents bacterial protein synthesis.
PC-60091

GSK-656

Mtb LeuRS inhibitor

GSK-656 (Ganfeborole; GSK-3036656, GSK656) is a potent, highly selective,orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
PC-60061

LL-3858 dihydrchloride

Anti-tuberculosis agent

Sudoterb (LL-3858) dihydrchloride is a novel anti-TB agent that has an MIC range of 0.06-0.5 ug/mL.
PC-60060

LL-3858

Anti-tuberculosis agent

Sudoterb (LL-3858, LL3858) is a novel anti-TB agent that has an MIC range of 0.06-0.5 ug/mL.
PC-60037

Delpazolid

Antibiotic

Delpazolid (LCB01-0371) is an oxazolidinone antibiotic that shows good antibacterial activity (MSSA MIC50=1 ug/mL).
PC-45637

Ribocil

FMN riboswitch inhibitor

Ribocil is a synthetic mimic of riboflavin 5’-monophosphate (FMN) that competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB.
PC-45713

N-Acetyl-Calicheamicin

N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic.
PC-45703

LED209

QseC inhibitor

LED209 is a bacterial conserved membrane histidine sensor kinase QseC inhibitor.
PC-47495

Cecropin B

Antibacterial

Cecropin B is an antimicrobial peptide with MICs (0.5 to 16 ug/ml) against Gram negative strain, also inhibit the expression of CYP3A29.
PC-45135

Retapamulin

Antibacterial

Retapamulin (SB275833) is an pleuromutilin antibiotic, specifically a protein synthesis inhibitor by interacting on the 50S subunit of the bacterial ribosome, binds to both E. coli and S. aureus ribosomes with Kd of 3 nM.
PC-42559

Sutezolid

Anti-tuberculosis agent

Sutezolid (PNU-100480, PF-02341272) is an oxazolidinone antibiotic that possesses potent antituberculosis activity in vitro and in vivo, by inhibiting bacterial protein synthesis.

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