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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-45637

Ribocil

FMN riboswitch inhibitor

Ribocil is a synthetic mimic of riboflavin 5’-monophosphate (FMN) that competes with the natural ligand to inhibit FMN riboswitch-mediated expression of ribB.
PC-45713

N-Acetyl-Calicheamicin

N-Acetyl-Calicheamicin is a enediyne antitumor antibiotic.
PC-45703

LED209

QseC inhibitor

LED209 is a bacterial conserved membrane histidine sensor kinase QseC inhibitor.
PC-47495

Cecropin B

Antibacterial

Cecropin B is an antimicrobial peptide with MICs (0.5 to 16 ug/ml) against Gram negative strain, also inhibit the expression of CYP3A29.
PC-45135

Retapamulin

Antibacterial

Retapamulin (SB275833) is an pleuromutilin antibiotic, specifically a protein synthesis inhibitor by interacting on the 50S subunit of the bacterial ribosome, binds to both E. coli and S. aureus ribosomes with Kd of 3 nM.
PC-42559

Sutezolid

Anti-tuberculosis agent

Sutezolid (PNU-100480, PF-02341272) is an oxazolidinone antibiotic that possesses potent antituberculosis activity in vitro and in vivo, by inhibiting bacterial protein synthesis.
PC-42560

Eperezolid

Antibacterial

Eperezolid (PNU-100592) is an oxazolidinone antibiotic that possesses potent antimicrobial activity in vitro and in vivo, binds specifically to the 50S ribosomal subunit of Escherichia coli.
PC-42178

Lenampicillin hydrochloride

Beta-lactam antibiotic

Lenampicillin hydrochloride (KBT1585) is an efficient prodrug of ampicillin with enhanced absorption and decreased side effects, inhibits bacterial penicillin-binding proteins (transpeptidase), an effective beta-lactam antibacterial agent.
PC-47423

Norvancomycin hydrochloride

Antibiotic

Norvancomycin hydrochloride (Desmethyl-vancomycin hydrochloride) is an antibiotic used to treat a number of bacterial infections that acts by inhibiting proper cell wall synthesis.
PC-46819

Vancomycin

Antibiotic

Vancomycin is an antibiotic used to treat a number of bacterial infections that acts by inhibiting proper cell wall synthesis.
PC-45750

Vaborbactam

serine β-lactamase inhibitor

Vaborbactam (RPX-7009) is a serine β-lactamase inhibitor that notably restores the activity of carbapenems against KPC-producing strains.
PC-45277

Garenoxacin mesylate hydrate

Antibiotic

Garenoxacin mesylate hydrate (BMS284756) is a quinolone antibiotic for the treatment of Gram-positive and Gram-negative bacterial infections.

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