Durlobactam (ETX2514) | β-lactamase inhibitor | Probechem Biochemicals

Chemical Structure : Durlobactam

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Durlobactam (ETX2514 free base, ETX-2514 free base)

货号: PC-35447Not For Human Use, Lab Use Only.

Durlobactam (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A β-lactamase KPC-2, class AmpC and class D OXA-24, respectively.

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生物&药学活性

Durlobactam (ETX2514) is a broad-spectrum β-lactamase inhibitor with IC50 of 4, 14 and 190 nM for class A β-lactamase KPC-2, class AmpC and class D OXA-24, respectively.

Durlobactam (ETX2514) potently inhibits clinically relevant class A, C and D β-lactamases and penicillin-binding proteins, resulting in intrinsic antibacterial activity against Enterobacteriaceae and restoration of β-lactam activity in a broad range of MDR Gram-negative pathogens.

Combination of sulbactam and ETX2514 shows potent antibacterial activity, in vivo efficacy against MDR A. baumannii infections.

物理化学性质&存储条件

分子量	277.251
分子式	C8H11N3O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl hydrogen sulfate

参考文献

1. Durand-Réville TF, et al. Nat Microbiol. 2017 Jun 30;2:17104.
2. McLeod SM, et al. Antimicrob Agents Chemother. 2018 Jan 25;62(2):e01576-17.

Durlobactam (ETX2514 free base, ETX-2514 free base)

生物&药学活性

物理化学性质&存储条件

参考文献

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Durlobactam (ETX2514 free base, ETX-2514 free base)

生物&药学活性

物理化学性质&存储条件

参考文献

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