SIG1459 | Antibacterial, TLR2 inhibitor | Probechem Biochemicals

Chemical Structure : SIG1459

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SIG1459 (SIG-1459, SIG 1459)

货号: PC-35771Not For Human Use, Lab Use Only.

SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling.

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25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SIG1459 (SIG-1459) is a novel anti-acne isoprenylcysteine (IPC) small molecule that shows direct antibacterial activity and inhibits TLR2 inflammatory signaling.
SIG1459 shows antibacterial activity against C. acnes (MIC= 8.5 uM, MBC =16.1 uM, and MBEC= 12.5 uM), inhibits TLR2 induced IL-8 release from TLR2/TLR2 (IC50= 0.086 uM), TLR2/6 (IC50= 0.209 uM) and IL-1α from TLR2/TLR2 (IC50 =0.050 uM).
SIG1459 demonstrates in vivo anti-acne activity.

物理化学性质&存储条件

分子量	584.768
分子式	C29H50N2Na2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(((1R)-1-carboxy-2-(((E)-3,7,11,15-tetramethylhexadec-2-en-1-yl)thio)ethyl)carbamoyl)proline disodium salt

参考文献

1. Fernández JR, et al. Exp Dermatol. 2018 Sep;27(9):993-999.

SIG1459 (SIG-1459, SIG 1459)

生物&药学活性

物理化学性质&存储条件

参考文献

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SIG1459 (SIG-1459, SIG 1459)

生物&药学活性

物理化学性质&存储条件

参考文献

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