P516-0475 |CAS:1359627-33-0 Probechem Biochemicals

Chemical Structure : P516-0475

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P516-0475

货号: PC-35094Not For Human Use, Lab Use Only.

P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO (IC50=10 uM).

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生物&药学活性

P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO (IC50=10 uM).
P516-0475 specifically induces expression of Rgg2/3-regulated genes in the presence of SHP pheromones at concentrations lower than typically required for QS induction.
P516-0475 directly inhibits recombinant PepO in vitro as an uncompetitive inhibitor, induces QS by stabilizing SHP pheromones in culture.

物理化学性质&存储条件

分子量	315.333
分子式	C15H17N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-methoxypropyl)-7-methyl-4-oxo-4,5-dihydro-[1,2,3]triazolo[1,5-a]quinoxaline-3-carboxamide

参考文献

1. Pérez Morales TG, et al. J Biol Chem. 2018 Jan 19;293(3):931-940.

P516-0475

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物理化学性质&存储条件

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P516-0475

生物&药学活性

物理化学性质&存储条件

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