VB-82252 | TcdB inhibitor | Probechem Biochemicals

Chemical Structure : VB-82252

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VB-82252 (VB82252)

货号: PC-35006Not For Human Use, Lab Use Only.

VB-82252 is a highly potent, orally active inhibitor of C. difficile toxins TcdA and TcdB, potently inhibits UDP glucose hydrolysis activity of TcdB (IC50=32 nM).

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生物&药学活性

VB-82252 is a highly potent, orally active inhibitor of C. difficile toxins TcdA and TcdB, potently inhibits UDP glucose hydrolysis activity of TcdB (IC50=32 nM).
VB-82252 protects CHO-K1 cells against challenge with purified TcdA (IC50 = 5.0 uM) or TcdB (IC50=0.25 uM).
VB-82252 prevents inflammation in murine intrarectal toxin challenge model, reduces weight loss and gut inflammation during acute disease in murine model of recurrent Clostridium difficile infection (CDI), demonstrates efficacy similar to that of vancomycin.

物理化学性质&存储条件

分子量	614.406
分子式	C29H20Cl2F3N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-chloro-4-((8-chloro-2,5-dioxo-3-(pyridin-2-ylmethyl)-1,2,3,5-tetrahydro-4H-benzo[e][1,4]diazepin-4-yl)methyl)-N-(5-(trifluoromethyl)pyridin-2-yl)benzamide

参考文献

1. Stroke IL, et al. Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e00107-18.

VB-82252 (VB82252)

生物&药学活性

物理化学性质&存储条件

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VB-82252 (VB82252)

生物&药学活性

物理化学性质&存储条件

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