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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-NOSO-502
NOSO-502

Chemical Structure : NOSO-502

CAS No.: 1894081-09-4

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NOSO-502 (NOSO502, NOSO 502)

货号: PC-35372Not For Human Use, Lab Use Only.

NOSO-502 (NOSO502) is a novel inhibitor of bacterial translation, has MIC values of 0.5-4 ug/ml against standard Enterobacteriaceae strains and carbapenem-resistant Enterobacteriaceae (CRE) isolates that produce KPC, AmpC, or OXA enzymes and metallo-β-lactamases.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NOSO-502 (NOSO502) is a novel inhibitor of bacterial translation, has MIC values of 0.5-4 ug/ml against standard Enterobacteriaceae strains and carbapenem-resistant Enterobacteriaceae (CRE) isolates that produce KPC, AmpC, or OXA enzymes and metallo-β-lactamases.
    NOSO-502 interacts strongly with a specific site on the 30S subunit of bacterial ribosomes but has no significant activity against any of the 55 cell surface receptors, transporters, or ion channels.
    NOSO-502 is active against a panel of Gram-positive and Gram-negative bacteria, including carbapenem-resistant and polymyxin-resistant strains, and exhibits promising in vivo activity in various murine infection models, a favorable in vitro safety profile, and a low potential for resistance development.

    物理化学性质&存储条件

    分子量 1078.263
    分子式 C47H80FN17O11
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-2-((S)-6-amino-2-((S)-2-((S)-1-((2R,8S,11S,14S)-14,18-diamino-11-((S)-2-amino-1-hydroxyethyl)-8-(2-aminoethyl)-2-(3-aminopropyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazaoctadecanoyl)pyrrolidine-2-carboxamido)-3-(2-fluorophenyl)propanamido)hexanamido)-5-gu

    参考文献

    1. Racine E, et al. Antimicrob Agents Chemother. 2018 Jul 9. pii: AAC.01016-18.

    2. Zhao M, et al. Antimicrob Agents Chemother. 2018 Jul 9. pii: AAC.01067-18.

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