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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial

Request The Product List ofBacterial Bacterial

Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

 
 

Cat. No. Product Name Information
PC-26545

L-161240

LpxC inhibitor

L-161240 (L-161,240) is an antibacterial agent that inhibit lipid A biosynthesis, inhibits LpxC with IC50 of 26 nM and inhibition constant (Ki) of 50 nM, displays MIC of about 1 ug /mL against Escherichia coli.
PC-26544

BB-78485

LpxC inhibitor

BB-78485 is a potent inhibitor of LpxC with IC50 of 160 nM in E. coli LpxC assays, showspredominantly gram-negative activities with MIC of 2 ug/mL for E.coli D21.
PC-26543

PF-5081090

LpxC inhibitor

PF-5081090 (LpxC-4) is a highly potent LpxC inhibitor with IC50 of 1.1 nM (P. aeruginosa LpxC) and MIC90 of 1 ug/mL, inhibits lipid A biosynthesis and is synergistic with azithromycin, rifampin, or vancomycin for multidrug-resistant A. baumannii.
PC-26482

S-0636

PgQC inhibitor

S-0636 is a potent, reversible inhibitor of zinc-dependent glutaminyl cyclase (PgQC) with Ki of 14 nM, selectively inhibits the bacterial virulence of P. gingivalis.
PC-26452

Aztreonam

Antibiotic

Aztreonam is a monocyclic beta-lactam antibiotic.
PC-26394

CP-20-I

AgrC inhibitor

CP-20-I is a specific small molecule inhibitor of quorum sensing receptor AgrC in Staphylococcus aureus with IC50 of 180 nM in group-I S. aureus transcriptional reporter assays.
PC-26393

AgrC inhibitor CP-20

AgrC inhibitor

AgrC inhibitor CP-20 is a specific small molecule inhibitor of quorum sensing receptor AgrC in Staphylococcus aureus with IC50 of 0.93 uM in group-I S. aureus transcriptional reporter assays.
PC-26321

Cefidelbaz

Cephalosporin antibiotic

Cefidelbaz is a cephalosporin antibiotic with significant antibacterial activity against gram-negative bacterium with MICs of 0.125-0.5, 0.125-0.5 and 0.125-2 μg/mL for carbapenem-resistant Acinetobacter baumannii (CRAB), Klebsiella pneumoniae (CRE) and Pseudomonas aeruginosa (CRPA), respectively.
PC-26175

CBR64

Bacterial RNA polymerase

CBR64 is a specific small molecule bacterial RNA polymerase (RNAP) inhibitor, inhibits catalytic activities of RNAP but not translocation of RNA or DNA, inhibits nucleotide addition.
PC-26174

CBR703

Bacterial RNA polymerase

CBR703 (C0340703) is a specific small molecule bacterial RNA polymerase (RNAP) inhibitor, inhibits catalytic activities of RNAP but not translocation of RNA or DNA, inhibits nucleotide addition.
PC-26173

AAP-SO2

Mtb RNAP inhibitor

AAP-SO2 is highly potent Mycobacterium tuberculosis (Mtb) RNA polymerase (RNAP) inhibitor with IC50 of 25 nM using an aptamer-based in vitro transcription assay, inhibits nucleotide addition, thereby reducing elongation and increasing termination rates.
PC-26172

MMV688845

M. abscessus inhibitor

MMV688845 ((R)-GSK1729177A) is a small molecule inhibitor of M. abscessus complex with MIC90 of 5-10 uM for various M. abscessus strains in vitro, targets the RpoB subunit of RNA polymerase, also shows anti-M. tuberculosis.

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