GM47-1

Chemical Structure : GM47-1

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货号: PC-26668Not For Human Use, Lab Use Only.

GM47-1 is small molecule inhibitor targeting MmpL3 in Mycobacterium abscessus, has MIC50 of 1.6 uM and trigger a dose-dependent ATP increase with EC50 of 3 uM in Mycobacterium abscessus.

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生物&药学活性

GM47-1 is small molecule inhibitor targeting MmpL3 in Mycobacterium abscessus, has MIC50 of 1.6 uM and trigger a dose-dependent ATP increase with EC50 of 3 uM in Mycobacterium abscessus.
GM47-1 also acts as an uncoupler, leading to a decrease in intracellular ATP levels and a cytochrome bcc:aa3-dependent increase in oxygen consumption.
GM47-1 is potent against clinical isolates, bactericidal in vitro, and potent against intracellular Mycobacterium abscessus (Mabs).
GM47-1 blocks trehalose monomycolate (TMM) transport to the outer membrane, and Mabs growth susceptibility is mmpL3 dependent.
GM47-1 induces extracellular ATP release and uncouples respiration, potentiates the activity of β-lactam antibiotics.

物理化学性质&存储条件

分子量	323.41
分子式	C21H22FNO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-ethoxyphenyl)-N-((4-fluoronaphthalen-1-yl)methyl)ethan-1-amine

参考文献

1. Singh S, et al. Cell Rep. 2026 Apr 22;45(5):117311.

GM47-1

生物&药学活性

物理化学性质&存储条件

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GM47-1

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物理化学性质&存储条件

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