Atuzaginstat (COR388) | Lysine-gingipain inhibitor | Probechem Biochemicals

Chemical Structure : COR388

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COR388 (Atuzaginstat)

货号: PC-72417Not For Human Use, Lab Use Only.

COR388 (Atuzaginstat) is an orally bioavailable, brain penetrant small-molecule that irreversibly inhibits lysine-gingipain (Kgp) with Ki of <0.01 nM.

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生物&药学活性

COR388 (Atuzaginstat) is an orally bioavailable, brain penetrant small-molecule that irreversibly inhibits lysine-gingipain (Kgp, gingipain K) with Ki of <0.01 nM.
COR388 blocks the activity of gingipains, a type of toxic protein made by the bacteria Porphyromonas gingivalis ( P. gingivalis ).
COR388 reduced the bacterial load of an established P. gingivalis brain infection, blocked Aβ1-42 production, reduced neuroinflammation, and rescued neurons in the hippocampus.

物理化学性质&存储条件

分子量	386.415
分子式	C19H25F3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility
Chemical Name/SMILES	(S)-N-(7-amino-2-oxo-1-(2,3,6-trifluorophenoxy)heptan-3-yl)cyclopentanecarboxamide

参考文献

1. Shirin Arastu-Kapur, et al. Pharmacol Res Perspect. 2020 Feb;8(1):e00562.

2. Stephen S Dominy, et al. Sci Adv. 2019 Jan 23;5(1):eaau3333.

3. Kenneth Barth, et al. Sci Rep. 2016 Oct 4;6:34656.

COR388 (Atuzaginstat)

生物&药学活性

物理化学性质&存储条件

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COR388 (Atuzaginstat)

生物&药学活性

物理化学性质&存储条件

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