Telacebec (Q203, IAP6) | Mtb QcrB inhibitor | Probechem Biochemicals

Chemical Structure : Q203

CAS No.: 1334719-95-7

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Q203 (Q-203, IAP6, Telacebec)

货号: PC-42302Not For Human Use, Lab Use Only.

Telacebec (Q203, IAP6) is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7 nM.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg	￥5880	In stock
100 mg		Get quote

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生物&药学活性

Telacebec (Q203, IAP6) is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB, inhibits M. tuberculosis H37Rv with MIC50 of of 2.7 nM.
Telacebec (Q203) does not inhibit any of thecytochrome P450 (CYP450) isoenzymes.
Telacebec (Q203) targets the respiratory cytochrome bc1 complex and triggers a rapid ATP depletion in M. tuberculosis, also inhibits the growth of MDR and XDR M. tuberculosis.
Telacebec (Q203) deonstrates potency in mouse model of tuberculosis and displays pharmacokinetic and safety profiles.

物理化学性质&存储条件

分子量	557.0064296
分子式	C29H28ClF3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 10 mM
Chemical Name/SMILES	Imidazo[1,2-a]pyridine-3-carboxamide, 6-chloro-2-ethyl-N-[[4-[4-[4-(trifluoromethoxy)phenyl]-1-piperidinyl]phenyl]methyl]-

参考文献

1. Pethe K, et al. Nat Med. 2013 Sep;19(9):1157-60.

2. Kang S, et al. J Med Chem. 2014 Jun 26;57(12):5293-305.

3. Jang J, et al. Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e02637-16.

Q203 (Q-203, IAP6, Telacebec)

生物&药学活性

物理化学性质&存储条件

参考文献

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Q203 (Q-203, IAP6, Telacebec)

生物&药学活性

物理化学性质&存储条件

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