Walrycin B |CAS:878419-78-4 Probechem Biochemicals

Chemical Structure : Walrycin B

CAS No.: 878419-78-4

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Walrycin B

货号: PC-45436Not For Human Use, Lab Use Only.

Walrycin B is a baterial WalR response regulator, an analogue of toxoflavin and a potent SARS-CoV-2 3CLpro inhibitor with IC50 of 0.26 uM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2280	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

Walrycin B is a baterial WalR response regulator, an analogue of toxoflavin and a potent SARS-CoV-2 3CLpro inhibitor with IC50 of 0.26 uM.
Walrycin B simultaneously affects the expression of WalR regulon genes, leading to phenotypes consistent with those of cells starved for the WalK/WalR system and having a bactericidal effect.
Walrycin B shows MICs of 0.39 mg/mL and 3.13 mg/mL against B. subtilis 168 and S. aureus N315, respectively.
Walrycin B also is a separase inhibitor, exerts potent anticancer efficacy in a mouse xenograft model.
Walrycin B has potent activity of inhibiting bacteria growth, and anticancer activity.

物理化学性质&存储条件

分子量	337.2567
分子式	C14H10F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 11.5 mg/mL
Chemical Name/SMILES	Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,6-dimethyl-3-[4-(trifluoromethyl)phenyl]-

参考文献

1. Gotoh Y, et al. J Antibiot (Tokyo). 2010 Mar;63(3):127-34.

Walrycin B

生物&药学活性

物理化学性质&存储条件

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Walrycin B

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物理化学性质&存储条件

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