QZN 34 | PqsR inhibitor | Probechem Biochemicals

Chemical Structure : QZN 34

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QZN 34 (QZN34, 3-C3NH2-7Cl-C9-QZN)

货号: PC-38406Not For Human Use, Lab Use Only.

QZN 34 is a small molecule pseudomonas aeruginosa PQS quorum-sensing system (PqsR) inhibitor with IC50 of 15 uM, kills planktonic Gram-positives (S. aureus, MIC 6.25 uM) but not Gram-negatives.

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生物&药学活性

QZN 34 is a small molecule pseudomonas aeruginosa PQS quorum-sensing system (PqsR) inhibitor with IC50 of 15 uM, kills planktonic Gram-positives (S. aureus, MIC 6.25 uM) but not Gram-negatives.
QZN 34 prevented S. aureus biofilm formation, severely damaged established S. aureus biofilms, and perturbed P. aeruginosa biofilm development.
QZN 34 killed planktonic Gram-positive pathogens including S. aureus, Staphylococcus epidermidis, Streptococcus pyogenes, and Clostridioides difficile but not Gram-negative bacteria such as P. aeruginosa and Escherichia. coli.
QZN 34 eradicated the mixed-species biofilm against mixed S. aureus and P. aeruginosa biofilms when combined with aminoglycoside.

物理化学性质&存储条件

分子量	363.930
分子式	C20H30ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-aminopropyl)-7-chloro-2-nonylquinazolin-4(3H)-one

参考文献

1. Ewan J Murray, et al. Cell Chem Biol. 2022 Mar 3:S2451-9456(22)00088-5.

QZN 34 (QZN34, 3-C3NH2-7Cl-C9-QZN)

生物&药学活性

物理化学性质&存储条件

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QZN 34 (QZN34, 3-C3NH2-7Cl-C9-QZN)

生物&药学活性

物理化学性质&存储条件

参考文献

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