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HSGN-189

Chemical Structure : HSGN-189

CAS No.: 2378181-36-1

HSGN-189 (HSGN189)

货号: PC-38636Not For Human Use, Lab Use Only.

HSGN-189 is a potent lipoteichoic acid (LTA) biosynthesis inhibitor, exhibits potent antibacterial activity against both MRSA and VRE strains with MICs of 1 ug/mL.

规格 价格 库存 数量
25 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    HSGN-189 is a potent lipoteichoic acid (LTA) biosynthesis inhibitor, exhibits potent antibacterial activity against both MRSA and VRE strains with MICs of 1 ug/mL.
    HSGN-189 demonstrated potent biofilm inhibition activity against MRSA and VRE biofilms.
    HSGN-189 potent synergized with the WTA inhibitor Tunicamycin in inhibiting MRSA and VRE biofilm formation.

    物理化学性质&存储条件

    分子量 522.543
    分子式 C24H25F3N4O4S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    4-(((3S,5R)-3,5-dimethylpiperidin-1-yl)sulfonyl)-3-methyl-N-(5-(4-(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2-yl)benzamide

    参考文献

    1. George A Naclerio, et al. Molecules. 2020 May 12;25(10):2277.

    2. Naclerio GA, et al. J Med Chem. 2022 Apr 28. doi: 10.1021/acs.jmedchem.1c02034.

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