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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-G0507
G0507

Chemical Structure : G0507

CAS No.: 1223998-29-5

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G0507 (G 0507)

货号: PC-62513Not For Human Use, Lab Use Only.

G0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity.

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10 mg ￥6980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

G0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity.
G0507 treatment results in accumulation of fully processed Lpp, an outer membrane lipoprotein, in the inner membrane in E. coli cells.
G0507 still binds to LolCDE harboring a LolCQ258K mutation, which confers high-level resistance to G0507 in vivo, but no longer stimulates ATPase activity.
G0507 is a useful chemical probe to dissect lipoprotein trafficking in Gram-negative bacteria.

物理化学性质&存储条件

分子量 353.396
分子式 C18H15N3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(4-methoxyphenyl)-6-(5-methylthiophen-2-yl)-1,7-dihydro-2H-pyrrolo[2,3-d]pyrimidine-2,4(3H)-dione

参考文献

1. Nickerson NN, et al. Antimicrob Agents Chemother. 2018 Jan 16. pii: AAC.02151-17.

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