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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-NITD-916
NITD-916

Chemical Structure : NITD-916

CAS No.: 1614262-83-7

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NITD-916 (NITD916)

货号: PC-62531Not For Human Use, Lab Use Only.

NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

NITD-916 is a novel, direct inhibitor of the mycobacterial enoyl-reductase InhA with IC50 of 0.57 uM, exhibits MIC50 of 50 nM against Mtb.
NITD-916 shows MIC of 0.04 to 0.16 μM against MDR-Mtb strains, binds specifically to InhA in an NADH-dependent manner and blocks the enoyl substrate-binding pocket.
NITD-916 shows in vivo efficacy in acute and established mouse models of Mycobacterium tuberculosis infection.

物理化学性质&存储条件

分子量 311.425
分子式 C20H25NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-((4,4-dimethylcyclohexyl)methyl)-4-hydroxy-3-phenylpyridin-2(1H)-one

参考文献

1. Manjunatha UH, et al. Sci Transl Med. 2015 Jan 7;7(269):269ra3.

2. McNeil MB, et al. Tuberculosis (Edinb). 2017 Dec;107:133-136.

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