TBAJ-876 |CAS:2332841-25-3 Probechem Biochemicals

Chemical Structure : TBAJ-876

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TBAJ-876 (TBAJ876)

货号: PC-38230Not For Human Use, Lab Use Only.

TBAJ-876 (TBAJ876) is a potent inhibitor of mycobacterial F-ATP synthase, inhibits ATP synthesis catalyzed by the mycobacterial F-ATP synthase with IC50 of 0.03 nM.

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生物&药学活性

TBAJ-876 (TBAJ876) is a potent inhibitor of mycobacterial F-ATP synthase, inhibits ATP synthesis catalyzed by the mycobacterial F-ATP synthase with IC50 of 0.03 nM.
TBAJ-876 shows depleting intrabacterial ATP (IC50=0.89 nM), and inhibiting growth of M. bovis BCG (MIC90=7.2 nM).
TBAJ-876 binds to the ε subunit at BDQ's binding site. TBAJ-876 shows attractive antitubercular activity and efficacy in a murine tuberculosis model.
TBAJ-876 shows attractive in vitro and in vivo activities against M. abscessus, similar to its BDQ parent.

物理化学性质&存储条件

分子量	657.562
分子式	C31H37BrN4O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)-1-(2,3,6-trimethoxypyridin-4-yl)butan-2-ol

参考文献

1. Jickky Palmae Sarathy, et al. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e01191-19.

2. Sarathy JP, et al. Antimicrob Agents Chemother. 2020 Jan 27;64(2):e01540-19.

3. Sarathy JP, et al. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e02404-19.

TBAJ-876 (TBAJ876)

生物&药学活性

物理化学性质&存储条件

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TBAJ-876 (TBAJ876)

生物&药学活性

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