2S-alkyne | SpeB inhibitor | Probechem Biochemicals

Chemical Structure : 2S-alkyne

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2S-alkyne (SpeB inhibitor 2S-alkyne)

货号: PC-38220Not For Human Use, Lab Use Only.

2S-alkyne is an irreversible and clickable inhibitor of Streptococcal pyrogenic exotoxin B (SpeB) with IC50 of 1.4 uM.

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生物&药学活性

2S-alkyne is an irreversible and clickable inhibitor of Streptococcal pyrogenic exotoxin B (SpeB) with IC50 of 1.4 uM.
2S-alkyne showed irreversible enzyme inhibition in biochemical assays and labeled endogenous SpeB in cultured S. pyogenes supernatants.
2S-alkyne decreased S. pyogenes survival in the presence of human neutrophils and supports the role of SpeB-mediated proteolysis as a mechanism to limit complement-mediated host defense.

物理化学性质&存储条件

分子量	392.371
分子式	C20H16N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-ethynylbenzyl (S)-(4-diazo-1-(3-nitrophenyl)-3-oxobutan-2-yl)carbamate

参考文献

1. Jordan L Woehl, et al. ACS Chem Biol. 2020 Aug 21;15(8):2060-2069.

2S-alkyne (SpeB inhibitor 2S-alkyne)

生物&药学活性

物理化学性质&存储条件

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2S-alkyne (SpeB inhibitor 2S-alkyne)

生物&药学活性

物理化学性质&存储条件

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