ML267 | Sfp-PPTase inhibitor | Probechem Biochemicals

Chemical Structure : ML267

CAS No.: 1542213-67-1

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ML267 (ML 267)

货号: PC-38041Not For Human Use, Lab Use Only.

ML267 (ML 267) is a potent, small-molecule inhibitor of bacterial phosphopantetheinyl transferase Sfp-PPTase with IC50 of 0.29 uM.

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5 mg	￥2480	In stock
10 mg	￥3980	In stock
50 mg	￥8980	In stock
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生物&药学活性

ML267 (ML 267) is a potent, small-molecule inhibitor of bacterial phosphopantetheinyl transferase Sfp-PPTase with IC50 of 0.29 uM.
ML267 displays no activity toward the human orthologue (hPPtase).
ML267 attenuates production of an Sfp-PPTase-dependent metabolite when applied to Bacillus subtilis at sublethal doses.
ML267 demonstrates antibacterial activity against methicillin-resistant Staphylococcus aureus, B. subtilis (HM489, IC50=9.3 uM) and chemical genetic studies implicated efflux as a mechanism for resistance in Escherichia coli.

物理化学性质&存储条件

分子量	431.862
分子式	C17H17ClF3N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide

参考文献

1. Foley TL, et al. J Med Chem. 2014 Feb 13;57(3):1063-78.

2. Konno S, et al. Chembiochem. 2017 Sep 19;18(18):1855-1862.

ML267 (ML 267)

生物&药学活性

物理化学性质&存储条件

参考文献

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ML267 (ML 267)

生物&药学活性

物理化学性质&存储条件

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