GSK693 (GSK2505693A) | Mtb InhA inhibitor | Probechem Biochemicals

Chemical Structure : GSK693

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GSK693 (GSK-693, GSK2505693A)

货号: PC-36157Not For Human Use, Lab Use Only.

GSK693 (GSK2505693A) is a potent, direct inhibitor of M. tuberculosis enoyl-ACP reductase (InhA) with IC50 of 7 nM, shows equally potent activity against M. tuberculosis H37Rv both intra and extracellularly (MIC=0.2 uM).

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生物&药学活性

GSK693 (GSK2505693A) is a potent, direct inhibitor of M. tuberculosis enoyl-ACP reductase (InhA) with IC50 of 7 nM, shows equally potent activity against M. tuberculosis H37Rv both intra and extracellularly (MIC=0.2 uM).
GSK693 exhibits activities against multidrug (MDR) and extensively (XDR) drug-resistant clinical isolates as well as in TB murine models when orally dosed.

物理化学性质&存储条件

分子量	419.54
分子式	C16H17N7OS3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(4-methylthiazol-2-yl)-1-(5-((1-((2-methylthiazol-4-yl)methyl)-1H-pyrazol-3-yl)amino)-1,3,4-thiadiazol-2-yl)ethanol

参考文献

1. Martínez-Hoyos M, et al. EBioMedicine. 2016 Jun;8:291-301.

GSK693 (GSK-693, GSK2505693A)

生物&药学活性

物理化学性质&存储条件

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GSK693 (GSK-693, GSK2505693A)

生物&药学活性

物理化学性质&存储条件

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