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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Vaborbactam
Vaborbactam

Chemical Structure : Vaborbactam

CAS No.: 1360457-46-0

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Vaborbactam (RPX-7009, RPX7009)

货号: PC-45750Not For Human Use, Lab Use Only.

Vaborbactam (RPX-7009) is a serine β-lactamase inhibitor that notably restores the activity of carbapenems against KPC-producing strains.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Vaborbactam (RPX-7009) is a serine β-lactamase inhibitor that notably restores the activity of carbapenems against KPC-producing strains.
Vaborbactam (RPX-7009) restores meropenem activity for 72.7 to 98.1% of CPE isolates at ≤2 ug/ml.
Vaborbactam (RPX-7009)  showes no antibacterial activity alone (MICs, >64 ug/ml).

物理化学性质&存储条件

分子量 297.1351
分子式 C12H16BNO5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 10 mM
Chemical Name/SMILES

1,2-Oxaborinane-6-acetic acid, 2-hydroxy-3-[[2-(2-thienyl)acetyl]amino]-, (3R,6S)-

参考文献

1. Castanheira M, et al. Antimicrob Agents Chemother. 2016 Aug 22;60(9):5454-8.

2. Hecker SJ, et al. J Med Chem. 2015 May 14;58(9):3682-92.

3. Griffith DC, et al. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6326-32.

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