BTZ043 | DprE1 inhibitor | Probechem Biochemicals

Chemical Structure : BTZ043

CAS No.: 1161233-85-7

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BTZ043 (BTZ-043, BTZ 043)

货号: PC-22472Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2380	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

BTZ043 is a small molecule antimycobacterial agent taregting the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase, shows MIC values of 1 ng/ml (2.3 nM) and 4 ng/ml (9.2 nM) against M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.
BTZ043 abolishes the formation of decaprenylphosphoryl arabinose, a key precursor that is required for the synthesis of the cell-wall arabinans, thus provoking cell lysis and bacterial death.

物理化学性质&存储条件

分子量	431.39
分子式	C17H16F3N3O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(2-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one

参考文献

1. Neres J, et al. Sci Transl Med. 2012 Sep 5;4(150):150ra121.

2. Vera-Cabrera L, et al. Antimicrob Agents Chemother. 2012 Jul;56(7):3984-5.

3. Makarov V, et al. Science. 2009 May 8;324(5928):801-4.

BTZ043 (BTZ-043, BTZ 043)

生物&药学活性

物理化学性质&存储条件

参考文献

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BTZ043 (BTZ-043, BTZ 043)

生物&药学活性

物理化学性质&存储条件

参考文献

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