CHIR-090 | LpxC inhibitor | Probechem Biochemicals

Chemical Structure : CHIR-090

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CHIR-090 (CHIR090)

货号: PC-23202Not For Human Use, Lab Use Only.

CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase, binds to E. coli LpxC with Ki of 4.0 nM, displays good antimicrobial activity against several Gram-negative bacteria.

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生物&药学活性

CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase, binds to E. coli LpxC with Ki of 4.0 nM, displays good antimicrobial activity against several Gram-negative bacteria.

物理化学性质&存储条件

分子量	437.50
分子式	C24H27N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((2S,3R)-3-Hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide

参考文献

1. McClerren AL, et al. Biochemistry. 2005 Dec 20;44(50):16574-83.

2. Barb AW, et al. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18433-8.

3. Bodewits K, et al. Antimicrob Agents Chemother. 2010 Aug;54(8):3531-3.

CHIR-090 (CHIR090)

生物&药学活性

物理化学性质&存储条件

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CHIR-090 (CHIR090)

生物&药学活性

物理化学性质&存储条件

参考文献

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