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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-CHIR-090
CHIR-090

Chemical Structure : CHIR-090

CAS No.: 728865-23-4

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CHIR-090 (CHIR090)

货号: PC-23202Not For Human Use, Lab Use Only.

CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase, binds to E. coli LpxC with Ki of 4.0 nM, displays good antimicrobial activity against several Gram-negative bacteria.

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5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase, binds to E. coli LpxC with Ki of 4.0 nM, displays good antimicrobial activity against several Gram-negative bacteria.

物理化学性质&存储条件

分子量 437.50
分子式 C24H27N3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-((2S,3R)-3-Hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide

参考文献

1. McClerren AL, et al. Biochemistry. 2005 Dec 20;44(50):16574-83.

2. Barb AW, et al. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18433-8.

3. Bodewits K, et al. Antimicrob Agents Chemother. 2010 Aug;54(8):3531-3.

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