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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Lefamulin
Lefamulin

Chemical Structure : Lefamulin

CAS No.: 1061337-51-6

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Lefamulin (BC3781, BC-3781)

货号: PC-22410Not For Human Use, Lab Use Only.

Lefamulin (BC-3781) is a pleuromutilin class of antimicrobial agent, inhibits bacterial protein synthesis by selectively binding to the peptidyl transferase center of the bacterial ribosome, prevents the correct positioning of the 3′-CCA ends of tRNAs for peptide transfer.

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10 mg ￥2980 In stock
25 mg ￥4780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Lefamulin (BC-3781) is a pleuromutilin class of antimicrobial agent, inhibits bacterial protein synthesis by selectively binding to the peptidyl transferase center of the bacterial ribosome, prevents the correct positioning of the 3′-CCA ends of tRNAs for peptide transfer.
Lefamulin (BC-3781) exhibits a log-normal MIC distribution against the population of S. pneumoniae, with modal MIC, MIC50, and MIC90 results of 0.12, 0.12, and 0.25 μg/ml, respectively.
Lefamulin (BC-3781) exhibits potent antibacterial activity against the most important respiratory and skin pathogens, including Streptococcus spp. and Staphylococcus spp., fastidious Gram-negative organisms, such as Haemophilus influenzae, and atypical respiratory pathogens, including Mycoplasma pneumoniae, Chlamydophila pneumoniae, and Legionella pneumophila.

物理化学性质&存储条件

分子量 507.73
分子式 C28H45NO5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-(((1R,2R,4R)-4-amino-2-hydroxycyclohexyl)thio)acetate

参考文献

1. Waites KB, et al. Antimicrob Agents Chemother. 2017 Jan 24;61(2):e02008-16.

2. Rubino CM, et al. Antimicrob Agents Chemother. 2015 Jan;59(1):282-8.

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