M4K2304

Chemical Structure : M4K2304

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货号: PC-22014Not For Human Use, Lab Use Only.

M4K2304 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 3 nM, >800-fold selective over ALK5.

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生物&药学活性

M4K2304 is a potent, selective BMP type I receptor ALK2 inhibitor with IC50 of 3 nM, >800-fold selective over ALK5.
M4K2304 shows cell IC50 of 11 nM in NanoBRET target engagement assay.
M4K2304 also shows high selectivity over ALK1 and ALK6, ALK4, as well as favorable kinome-wide selectivity.
M4K2304 demonstrates excellent kinome-wide selectivity, inhibiting only 3% of 422 kinases by more than 50% at 1 uM.

物理化学性质&存储条件

分子量	460.58
分子式	C27H32N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-methyl-9-(piperazin-1-yl)-4-(3,4,5-trimethoxyphenyl)-6,7-dihydro-5H-benzo[c]pyrido[3,4-e]azepine

参考文献

1. González-Álvarez H, et al. J Med Chem. 2024 Mar 18.

M4K2304

生物&药学活性

物理化学性质&存储条件

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M4K2304

生物&药学活性

物理化学性质&存储条件

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